- I-81 is the longest interstate in Virginia and rated one of the top eight truck routes in the U.S.
- Interstates 64 and 81 provide easy access to the Virginia Inland Port at Front Royal and The Port of Virginia in Hampton Roads.
- I-66 links I-81 with the Washington, D.C., MSA.
- Freight rail service is provided by CSX Transportation, Norfolk Southern, Buckingham Branch Railroad, Chesapeake & Western Railroad, and Shenandoah Valley Railroad.
- The Virginia Inland Port is 31 miles from the region and The Port of Virginia in Hampton Roads is 182 miles east.
- General aviation and commercial air service is provided by Shenandoah Valley Regional Airport (SHD), which offers Daily United Express jet service to Chicago O’Hare and Washington Dulles, as well as Charlottesville-Albemarle Airport (CHO – 36.7 miles), and Lynchburg Regional Airport (LYH – 40.3 miles).