- I-81 is the longest interstate in Virginia and rated one of the top eight truck routes in the U.S.
- I-77, just 3 miles south, connects the eastern Great Lakes region with Appalachia and the Southeast.
- The region offers quick access to I-64 (21 miles) and I-40 (44 miles).
- Freight rail service is provided by Norfolk Southern, offering a wide range of reliable and efficient shipping options.
- Passenger rail service provided by Amtrak is available from Roanoke (30 miles).
- The Virginia TradePort is located at the New River Valley Airport, and The Port of Virginia in Hampton Roads is 291 miles east
- The New River Valley Airport (PSK) and the Virginia Tech Montgomery Executive Airport (BCB) provide general aviation services, and commercial air service is available from Roanoke-Blacksburg Regional Airport (ROA), served by four airlines with approximately 40 arriving and departing flights per day and nonstop service to eight cities, as well as frequent connecting service.